It is considered the problem of forming of innovative environment in the region at the cost of relevant clusters separation and their development. Permsky Krai is considered as an example of the regional cluster, which was built on the basis of the national research university. The authors have suggested the conception of a cluster and the participants of innovative process as a system; measure set of entente cordiale forming within the bounds of regional innovation system; orientation for effective management of innovation; areas of science which are necessary for innovative activity support in the region.