Questions of the relationship between the results of structural changes in recent years and the conditions of economic security of different municipalities were analyzed in this paper. It was proven that the arrangements, elaborated and realized in the frames of programs of economic modernization, must consider threats of economic security of different subjects, including municipalities, which appeared in the real life in constraints of structural changes of economy and reforming its industrial structure. The system of economic security indexes and the nomenclature of different risks and security threats were created. The main indicators, which characterize economic security of municipal entities, were highlighted. The authors’ methodic of calculation procedure of economic municipalentities security was devised. An assessment of the level of economic security of municipalities has been held on the base of 47 municipalities of Perm territory. Features of the approaches to the definition of concept have been indentified and formulated on the basis of economic security indicators of municipalities.

The issue of sustainable socio-economic systems of different hierarchical levels, including the region, includes an extensive list of issues. The task of stimulating innovative activity, improving the competitiveness of the economy, while ensuring its security and stability occupy a special place among these issues. This paper analyzes the place and role of these processes to achieve sustainable socio-economic development. The author's theoretical approach to assessing the relationship of processes of innovation, competitiveness, maintain the economic security of the region and ensure its sustainable socio-economic development, based on the analysis of the leading Russian scientific schools in this area is presented.