The necessity of developing methodologies for assessing the business organization is substantiated. Creation of new business entities is seen as a tool of differentiation of the territory in order to diminish the emerging imbalances. The importance of assessing the value of business organization as a multifactoral process is characterized. Particular attention is paid to the development and testing methodologies of comprehensive assessment of entrepreneurial activity. A comparison of entrepreneurial activity in mono-cities of Asbest and Kamensk-Uralskiy is made and situation in the city of Yekaterinburg is shown for comparison. The results of the sociological survey aimed at identifying characteristics of potential entrepreneurs territories, where the predominant narrow economic specialization - in particular, such areas as mono-cities, are currently being analyzed. A comparison of the perceptions of business organizations by operating businesses and those who are not business entities was made on the following criteria: characteristics that distinguish the studied group, satisfaction with the amount of income, possible difficulties in the initial stages of business, perception of business etc. It is emphasized that the most important incentive for business is dissatisfaction with the current situation.

This paper takes notice of the mythology that has arisen in the scientific community regarding small business, and sets out the author's vision of how to solve some specific problems, including: separation and clarification of the terms "small-sized" and "medium-sized" business, the value of systematically organized monitoring of small manufacturing adn small businesses, and governmental support of such activity; keeping the balance of interests of economic entities, hired personnel and local (municipal and regional) authorities and the study of the real potential of small businesses and opportunities for its expansion, formation of the phenomenon of vicarious personal liability in this area of social and economic relations. In the single-industry regions and territorial entities, the small businesses in general and small manufacturings in particular are in an embryonic state. The actual formation of the latter is possible with proper scientific support of the processes justifying specific interventions and evaluating the prospects of development of this sector of the economy in terms of the impact on the socio-economic condition of the respective municipalities.

This paper describes social responsibility in regional studies as a base of scientific and practical position has an interdisciplinary character and is a key in economic theory topic, referred to as «behavioral economics». The strategic aspect of social behavior should eventually become a daily norm at all levels of administration and corporate governance in all spheres of human activity. Tactical objective of regional and municipal authorities is development and implementation of research-based socially responsible policy. The level of social responsibility cannot be measured using a single universal (integral) indicator. The idea that «The economics has as much science inside, as much as it has mathematics», as formulated in the XIX century, in the beginning of the XXI century should be rephrased the following way: «The economics has as much science inside, as much as it has humanity»