The basic problems of development of socio-demographic sphere in Sverdlovsk region at the present stage are considered. The methodical approach of the account of influence of the enterprises of the large integrated structures on indicators socio-demographic safety of territories of municipal level is presented. The approbation estimation of influence of the enterprises of the large integrated structures on socio-demographic safety on an example of municipal unions of Sverdlovsk region for 2000-2006 is executed.