In article the modern state and expansion potential of economic relations between Republic of Komi and the Ural regions are considered. Macrostructure, resource and innovational preconditions of formation macroregion Komi – Ural are designated. Institutional deficiency and transport restrictions are barriers of strengthening of inter-regional interrelations. It is important to expanse borders and contents of the transport corridor project "Ural Industrial – Ural Polar" and to transit to purposeful development perspective macroregion. The probable algorithm of scientific-organizational activity is offered.